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Research
New Device Will Improve Surgery On Hardened Arteries

Use of atypical antipsychotics in children and adolescents
Evidence on the efficacy and safety of with schizophrenia is limited. Toren et al. (2004) reviewed the literature on use of atypical antipsychotics in children and adolescents with schizophrenia. The major findings were: Risperidone, and possibly also olanzapine, may be the drugs of choice in children with comorbid tic disorders. Ziprasidone may be administered as an augmenting agent in children and adolescents with schizophrenia and comorbid anxiety and mood disorders. Risperidone, olanzapine and clozapine are effective in the treatment of aggression and mania. In children and adolescents receiving clozapine, olanzapine and quetiapine, particularly those with obesity or a family history of diabetes mellitus, fasting blood glucose and lipid levels must be monitored frequently. Weight gain might be better controlled when the children and their parents are properly informed about this adverse effect and diet is regulated. Hyperprolactinaemia is another major disadvantage of the atypical antipsychotics, especially risperidone. Hyperprolactinaemia can lead to hypogonadism-induced osteoporosis, galactorrhoea, gynaecomastia, irregular menstruation and sexual dysfunction. Other atypical antipsychotics, namely olanzapine and ziprasidone, have been reported to be prolactin sparing in adults, but may not be completely devoid of hyperprolactinaemic effects in children and adolescents. Thus, prolactin levels should be assessed routinely in young patients treated with atypical antipsychotics. Further, children and adolescents with hyperprolactinaemia-related effects should be switched to a prolactin-sparing agent, such as quetiapine. The use of typical antipsychotics has been limited to patients who are resistant to atypical antipsychotics, intolerant to their adverse effects, or require injections or depot preparations. Ref: - Toren, P., Ratner, S., Laor, N. & Weizman, A. (2004) Benefit-risk assessment of atypical antipsychotics in the treatment of schizophrenia and comorbid disorders in children and adolescents. Drug Safety, 27, 14, 1135-1156.

Corey Haim's Death Highlights Difficulty of Addiction Recovery
The death of 38-year-old actor Corey Haim by an alleged prescription drug overdose has cast renewed light on the question of whether an addict can truly "recover" -- particularly in light of accounts, including his own, that he had cleaned up his life.



CoreyHaim - Addiction - Health - Lost Boys - Substance abuse

Future Doctor
Up To Half Of Elderly Patients Are Dehydrated

WATCH: Abortion Language Delays Health Care Bill
Congressman Bart Stupak wants to remove public funding for abortions from Obama's proposal.



Abortion - Bart Stupak - Health - Reproductive Health - United States

Managing adverse effects of clozapine
Constipation: encourage high-fiber diet, adequate fluid intake, use of aperients if persistent Fever: Symptomatic relief, check full blood count and look for sources of infection Hypersalivation: Consider use of hyoscine hydrobromide (upto 300 mcg tds), pirenzepine (upto 50 mg tds) Hypertension: Monitor closely, slow rate or halt dose increase, if persistent consider use of hypotensive agent (e.g., atenolol) Hypotension: advise caution when getting up quickly, monitor closely, slow or halt dose increase. Nausea: Consider use of antiemetic (avoid metoclopramide and prochlorperazine if previous problems with extrapyramidal side effects). Neutropenia/agranulocytosis: Stop Clozapine, if outpatient admit to hospital Nocturnal enuresis: avoid fluids in the evening, alter dose scheduling, if severe consider use of desmopressin Sedation: reschedule dosing to give smaller morning or total dose Seizures: Withhold clozapine for 24 hours, recommence at lower dose, consider prophylactic anticonvulsant Weight gain: Dietary and exercise counseling Ref: - Semple, D., Smyth, R., Burns, J., Darjee, R. & McIntosh, A. (2005) Oxford Handbook of Psychiatry, New York: Oxford University Press.

WATCH: Deepak Chopra's Yoga Routine
The spiritual guru discusses his new yoga iPhone app.



Deepak Chopra - iPhone - Religion and Spirituality - Smartphones - Handhelds

WATCH: No More Lying on Food Labels
The FDA cracks down on 17 food manufacturers for misleading claims.



Food and Drug Administration - Business - United States - Printing - Products

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WATCH: Understanding Over-the-Counter Painkillers
Dr. Marie Savard explains how to select and use popular pain medications.



Health - Medicine - Medical Specialties - Marc Savard - Boston Bruins

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